Ameliorative effect of Allium atroviolaceum on sperm quality in cyclophosphamide-treated mice

Abstract Background Cyclophosphamide (CP) is an anti-neoplastic alkylating agent that extensively used in different chemotherapy regimens. Adverse effects on the reproductive system, especially spermatogenesis, are one of most important side this drug. It medically essential to use complementary and alternative drugs. Herbal drugs have long been as a treatment. Our purpose was study effect hydroalcoholic Allium atroviolaceum L. extract spermatogenesis CP-treated mice. Results CP affected significant decrease sperm count, motility, viability, morphology. Sperm count significantly higher all groups than group control ( p <0.001) <0.001, <0.01). motility greater (100 200mg/kg) <0.05 <0.001). immotility rotational movement were CP+extract The viability (200mg/kg) number headless sperm, with initial tail, coiled curved body, lower Conclusion A. treatment improved CP-induced toxicity.